Post-docs and students Details: Vincent Breton-Provencher Ph.D. Student
Phone: (418) 663-5000 ext. 6808
Figure 1: 2 photons microscopy images of adult born cell dendrites obtained from mouse OB slices. The cells were labelled with a virus encoding a green fluorescent protein (GFP).
The olfactory bulb (OB) is a region of the mammalian central nervous system that receives a continuous supply of new neurons during adulthood. Little is known, however, on the mechanisms controlling the integration and maturation of the new cells into the pre-existing neuronal circuitry. The aim of my study is to characterize the cellular and molecular cues orchestrating this integration. By using innovative microscopy techniques along with electrophysiological recordings I investigate both morphological and functional properties of integrating cells. My research is also focussed on the molecular signals that the already existing bulbar circuitry cells employ to control integration of newborn cells. These results will be essential not only for the complete understanding of the mechanisms governing adult neurogenesis, but also for the development of new strategies for cell replacement therapies to cure neurodegenerative diseases and brain trauma. |
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