Groupe de Recherche Groupe de Recherche
Research Areas
Animal models, Behavioral study (mice), Biochemistry, Surgery (mice), Molecular Biology, Cell Culture, Neuropharmacology, Microscopy (Opt&Elec), Transgenic/knockout, siRNA.
Research Description
Research in this laboratory is oriented around structure/property relationships of classes of molecules which form interfaces and nanomaterials. This takes us into molecular design and synthesis (of novel surfactants and lipids), kinetics studies (enzymology), surface chemical techniques (Langmuir films, electrochemistry, scanning probe microscopy), spectroscopy (NMR, IR) and polymer chemistry. In addition to the research that is performed directly in our labs, we also work with researchers in Physiology, Physics, Chemical Engineering, and Neurosciences on collaborative projects.
Research Areas
Video rate microscopy for multimodal live animal imaging, Coherent Raman development for live imaging, Microendoscopic imaging of brain structures, Fast optical measurements of neuronal activity.
Research Description
Our lab investigates the cellular and molecular mechanisms used by neurons to decode synaptic and electrical activities that propagate through neural circuits. We are particularly interested in learning how these mechanisms contribute to synaptic remodeling and to the maintenance and modifications of brain circuit connectivity. Synaptic remodelling in the brain during development and in adult life is thought to represent fundamental cellular processes of learning and memory.
Research Areas
Spinal cord, sensory physiology, synaptic transmission, pain, electrophysiology, patch clamp, biophysics, cellular maging, fluorescence spectroscopy, nanoprobes.
Research Interests
My research interests are focused on scanning probe microscopy and the interdisciplinary application of these techniques. At the nanometer level, the traditional boundaries between physics, chemistry, engineering and the life sciences vanish. Physics, and in particular a background in scanning probe techniques, is an excellent basis to contribute significantly to the emerging field of nanotechnology.
Research Interests
My research interests are in nonlinear dynamics, stochastic dynamics, computational neuroscience, biological physics and mathematical biology. The main focus of my research is on theoretical and computational studies of the nervous system.
Leonard Maler
Dr. Maler's research has focused on feedback input in the electrosensory system, which is especially amenable to detailed analysis at both the circuit and cellular levels.
Research Areas
Basal Ganglia, Postnatal Neurogenesis, Neurodegenerative Disord., Animal Models, Neuroanatomy, Immunocytochemistry, Human Brain Banking, Comparative Neurology, Single-Cell Labeling
Research objectives of our group are:
To elucidate the cellular and molecular mechanisms governing adult neurogenesis. To employ these mechanisms for cell replacement therapies in animal models of neurodegenerative diseases and stroke. To understand the functional role of adult OB neurogenesis.
Research Interests
We use a combination of patch-clamp whole-cell electrophysiology and two-photon microscopy in mouse acute hippocampal slices to study: The physiological properties of ISIs, input-specific synaptic integration, the properties of inhibitory synapses made by ISIs onto their GABAergic targets, the role of ISIs in the regulation of O-LM interneuron function and network operation.
Research Interests
Biophysical chemistry with an emphasis on measuring macromolecular interactions in living cells using single photon and two-photon variants of image correlation spectroscopy (ICS) and image cross-correlation spectroscopy (ICCS).
Live cell measurements of macromolecular dynamics and clustering phenomena of green fluorescent protein (GFP) integrin constructs to study their role in assembly of cell adhesion structures and in receptor "cross-talk" with other signaling systems in cells.